Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico.
Arch Virol
; 162(12): 3629-3637, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-28819692
ABSTRACT
Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rabies
/
Rabies virus
/
Dog Diseases
/
Genotype
Limits:
Animals
/
Humans
Country/Region as subject:
Mexico
Language:
En
Journal:
Arch Virol
Year:
2017
Type:
Article
Affiliation country:
Mexico