Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant.

Ohanyan, Tatevik; Schoepke, Nicole; Eirefelt, Stefan; Hoey, Gert; Koopmann, Witte; Hawro, Tomasz; Maurer, Marcus; Metz, Martin

Ohanyan, Tatevik; Schoepke, Nicole; Eirefelt, Stefan; Hoey, Gert; Koopmann, Witte; Hawro, Tomasz; Maurer, Marcus; Metz, Martin.

Affiliation

Ohanyan T; Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, DE-10117 Berlin, Germany.

Acta Derm Venereol ; 98(1): 26-31, 2018 Jan 12.

Article in En | MEDLINE | ID: mdl-28853492

Subject(s)

Morpholines/therapeutic use; Neurokinin-1 Receptor Antagonists/therapeutic use; Prurigo/drug therapy; Prurigo/metabolism; Receptors, Neurokinin-1/metabolism; Substance P/blood; Administration, Cutaneous; Aged; Aprepitant; Case-Control Studies; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Morpholines/administration & dosage; Neurokinin-1 Receptor Antagonists/administration & dosage; Proof of Concept Study; Prospective Studies; Prurigo/complications; Pruritus/etiology; Severity of Illness Index; Visual Analog Scale

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prurigo / Substance P / Morpholines / Receptors, Neurokinin-1 / Neurokinin-1 Receptor Antagonists Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Acta Derm Venereol Year: 2018 Type: Article Affiliation country: Germany

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