Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity.

Gorsky, Marianna Karina; Burnouf, Sylvie; Sofola-Adesakin, Oyinkan; Dols, Jacqueline; Augustin, Hrvoje; Weigelt, Carina Marianne; Grönke, Sebastian; Partridge, Linda

Gorsky, Marianna Karina; Burnouf, Sylvie; Sofola-Adesakin, Oyinkan; Dols, Jacqueline; Augustin, Hrvoje; Weigelt, Carina Marianne; Grönke, Sebastian; Partridge, Linda.

Affiliation

Gorsky MK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.
Burnouf S; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.
Sofola-Adesakin O; Institute of Healthy Ageing, and GEE, UCL, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Dols J; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.
Augustin H; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.
Weigelt CM; Institute of Healthy Ageing, and GEE, UCL, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Grönke S; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.
Partridge L; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931, Cologne, Germany.

Sci Rep ; 7(1): 9984, 2017 08 30.

Article in En | MEDLINE | ID: mdl-28855586

Subject(s)

Amyloid beta-Peptides/metabolism; Amyloid beta-Peptides/toxicity; Microtubules/metabolism; Protein Processing, Post-Translational; tau Proteins/metabolism; Acetylation; Animals; Drosophila; Gene Expression; Gene Knock-In Techniques; Gene Knockout Techniques; Humans; Models, Animal; Phosphorylation; Protein Binding; Protein Multimerization; Recombinant Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Processing, Post-Translational / Amyloid beta-Peptides / Tau Proteins / Microtubules Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: Germany

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