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Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.
Dubrovskaya, Viktoriya; Guenaga, Javier; de Val, Natalia; Wilson, Richard; Feng, Yu; Movsesyan, Arlette; Karlsson Hedestam, Gunilla B; Ward, Andrew B; Wyatt, Richard T.
Affiliation
  • Dubrovskaya V; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
  • Guenaga J; IAVI Neutralizing Center at TSRI, Department of Research and Development, International AIDS Vaccine Initiative, La Jolla, California, United States of America.
  • de Val N; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
  • Wilson R; IAVI Neutralizing Center at TSRI, Department of Research and Development, International AIDS Vaccine Initiative, La Jolla, California, United States of America.
  • Feng Y; IAVI Neutralizing Center at TSRI, Department of Research and Development, International AIDS Vaccine Initiative, La Jolla, California, United States of America.
  • Movsesyan A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
  • Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Ward AB; IAVI Neutralizing Center at TSRI, Department of Research and Development, International AIDS Vaccine Initiative, La Jolla, California, United States of America.
  • Wyatt RT; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
PLoS Pathog ; 13(9): e1006614, 2017 Sep.
Article in En | MEDLINE | ID: mdl-28902916
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / HIV Antibodies / Env Gene Products, Human Immunodeficiency Virus / Antibodies, Neutralizing Limits: Animals Language: En Journal: PLoS Pathog Year: 2017 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / HIV Antibodies / Env Gene Products, Human Immunodeficiency Virus / Antibodies, Neutralizing Limits: Animals Language: En Journal: PLoS Pathog Year: 2017 Type: Article Affiliation country: United States