Polymorphism in CYP2D6 affects the pharmacokinetics and dose escalation of paroxetine controlled-release tablet in healthy Chinese subjects.

Chen, Rui; Shen, Kai; Hu, Pei

Chen, Rui; Shen, Kai; Hu, Pei.

Int J Clin Pharmacol Ther ; 55(11): 853-860, 2017 Nov.

Article in En | MEDLINE | ID: mdl-28933337

Subject(s)

Cytochrome P-450 CYP2D6/genetics; Paroxetine/administration & dosage; Selective Serotonin Reuptake Inhibitors/administration & dosage; Adult; Area Under Curve; Asian People; Chromatography, Liquid; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Humans; Male; Paroxetine/pharmacokinetics; Polymorphism, Genetic; Selective Serotonin Reuptake Inhibitors/pharmacokinetics; Tablets; Tandem Mass Spectrometry; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selective Serotonin Reuptake Inhibitors / Paroxetine / Cytochrome P-450 CYP2D6 Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Int J Clin Pharmacol Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Type: Article

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