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Massively parallel de novo protein design for targeted therapeutics.
Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J; Hicks, Derrick R; Vergara, Renan; Murapa, Patience; Bernard, Steffen M; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T; Koday, Merika T; Jenkins, Cody M; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M; Fernández-Velasco, D Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A; Fuller, Deborah H; Baker, David.
Affiliation
  • Chevalier A; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Silva DA; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Rocklin GJ; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Hicks DR; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Vergara R; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Murapa P; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Bernard SM; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Zhang L; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Lam KH; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA.
  • Yao G; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Bahl CD; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Miyashita SI; Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, México City 04510, Mexico.
  • Goreshnik I; Department of Microbiology, University of Washington, Seattle, Washington 98109, USA.
  • Fuller JT; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
  • Koday MT; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
  • Jenkins CM; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
  • Colvin T; Department of Chemistry and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Carter L; Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA.
  • Bohn A; Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA.
  • Bryan CM; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Fernández-Velasco DA; Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
  • Stewart L; Department of Urology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Dong M; Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Huang X; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
  • Jin R; Department of Microbiology, University of Washington, Seattle, Washington 98109, USA.
  • Wilson IA; Department of Microbiology, University of Washington, Seattle, Washington 98109, USA.
  • Fuller DH; Virvio Inc., Seattle, Washington 98195, USA.
  • Baker D; Department of Microbiology, University of Washington, Seattle, Washington 98109, USA.
Nature ; 550(7674): 74-79, 2017 10 05.
Article in En | MEDLINE | ID: mdl-28953867
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Protein Engineering / Proteins / Influenza, Human / Molecular Targeted Therapy Limits: Humans Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Protein Engineering / Proteins / Influenza, Human / Molecular Targeted Therapy Limits: Humans Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States