Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review.
Ophthalmol Ther
; 6(2): 263-276, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-28956287
ABSTRACT
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE®) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Ophthalmol Ther
Year:
2017
Type:
Article
Affiliation country:
United States