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Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer.
Smith, Zachary D; Shi, Jiantao; Gu, Hongcang; Donaghey, Julie; Clement, Kendell; Cacchiarelli, Davide; Gnirke, Andreas; Michor, Franziska; Meissner, Alexander.
Affiliation
  • Smith ZD; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Shi J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Gu H; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Donaghey J; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Clement K; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Cacchiarelli D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Gnirke A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Michor F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Meissner A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Nature ; 549(7673): 543-547, 2017 09 28.
Article in En | MEDLINE | ID: mdl-28959968

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Gene Expression Regulation, Developmental / Cell Lineage / DNA Methylation / Epigenesis, Genetic / Ectoderm / Germ Layers / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Gene Expression Regulation, Developmental / Cell Lineage / DNA Methylation / Epigenesis, Genetic / Ectoderm / Germ Layers / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: Nature Year: 2017 Type: Article Affiliation country: United States