Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.

McCoy, Sara S; Reed, Tamra J; Berthier, Celine C; Tsou, Pei-Suen; Liu, Jianhua; Gudjonsson, Johann E; Khanna, Dinesh; Kahlenberg, J Michelle

McCoy, Sara S; Reed, Tamra J; Berthier, Celine C; Tsou, Pei-Suen; Liu, Jianhua; Gudjonsson, Johann E; Khanna, Dinesh; Kahlenberg, J Michelle.

Affiliation

McCoy SS; Department of Internal Medicine, Division of Rheumatology, University of Wisconsin, Madison, WI.
Reed TJ; Department of Internal Medicine, Division of Rheumatology.
Berthier CC; Department of Internal Medicine, Division of Nephrology.
Tsou PS; Department of Internal Medicine, Division of Rheumatology.
Liu J; Department of Internal Medicine, Division of Rheumatology.
Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Khanna D; Department of Internal Medicine, Division of Rheumatology.
Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology.

Rheumatology (Oxford) ; 56(11): 1970-1981, 2017 11 01.

Article in En | MEDLINE | ID: mdl-28968684

Subject(s)

Cell Differentiation; Fibroblasts/cytology; Keratinocytes/cytology; Scleroderma, Systemic/metabolism; Transforming Growth Factor beta/metabolism; Actins/metabolism; Adult; Aged; Cells, Cultured; Chemokine CCL5/genetics; Chemokine CCL5/metabolism; Collagen Type I/genetics; Collagen Type I/metabolism; Collagen Type I, alpha 1 Chain; Culture Media, Conditioned; Down-Regulation; Female; Fibroblasts/metabolism; Fibrosis; Gene Expression Profiling; Humans; Immunohistochemistry; Keratinocytes/metabolism; Male; Middle Aged; NF-kappa B/metabolism; PPAR gamma/metabolism; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Scleroderma, Diffuse; Scleroderma, Localized; Scleroderma, Systemic/genetics; Scleroderma, Systemic/pathology; Skin/pathology; Up-Regulation

Key words

CCL5; NF-κB; PPAR-Î³; TGF-ß; fibroblast; keratinocyte; scleroderma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scleroderma, Systemic / Keratinocytes / Cell Differentiation / Transforming Growth Factor beta / Fibroblasts Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2017 Type: Article

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