Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration.

Biswas, Lincoln; Zhou, Xinzhi; Dhillon, Baljean; Graham, Annette; Shu, Xinhua

Biswas, Lincoln; Zhou, Xinzhi; Dhillon, Baljean; Graham, Annette; Shu, Xinhua.

Affiliation

Biswas L; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4?0BA, UK.
Zhou X; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4?0BA, UK.
Dhillon B; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16?4SB, UK.
Graham A; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4?0BA, UK.
Shu X; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4?0BA, UK.

Hum Mol Genet ; 26(22): 4327-4339, 2017 11 15.

Article in En | MEDLINE | ID: mdl-28973423

Subject(s)

Cholesterol/metabolism; Macular Degeneration/drug therapy; Macular Degeneration/metabolism; Receptors, GABA/metabolism; Retinal Pigment Epithelium/metabolism; Biological Transport; Carrier Proteins/metabolism; Cells, Cultured; Humans; Indoleacetic Acids/pharmacology; Ligands; Lipoproteins, LDL/metabolism; Mitochondria/metabolism; Molecular Targeted Therapy; Oxazines/pharmacology; Oxidative Stress; Pancreatic Elastase/metabolism; Purines/pharmacology; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Receptors, GABA / Retinal Pigment Epithelium / Macular Degeneration Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Type: Article Affiliation country: United kingdom

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