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Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis.
Miyazaki, Yusei; Niino, Masaaki; Takahashi, Eri; Suzuki, Masako; Mizuno, Masanori; Hisahara, Shin; Fukazawa, Toshiyuki; Amino, Itaru; Nakano, Fumihito; Nakamura, Masakazu; Akimoto, Sachiko; Minami, Naoya; Fujiki, Naoto; Doi, Shizuki; Shimohama, Shun; Terayama, Yasuo; Kikuchi, Seiji.
Affiliation
  • Miyazaki Y; Department of Clinical Research, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan. Electronic address: yuseimiyazaki@hok-mc.hosp.go
  • Niino M; Department of Clinical Research, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Takahashi E; Department of Clinical Research, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Suzuki M; Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
  • Mizuno M; Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
  • Hisahara S; Department of Neurology, Sapporo Medical University School of Medicine, Minami-1-jo Nishi-17-chome, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan.
  • Fukazawa T; Sapporo Neurology Hospital, 2-17 Kita-21-jo Higashi-21-chome, Higashi-ku, Sapporo, Hokkaido 065-0021, Japan.
  • Amino I; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Nakano F; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Nakamura M; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Akimoto S; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Minami N; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Fujiki N; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Doi S; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
  • Shimohama S; Department of Neurology, Sapporo Medical University School of Medicine, Minami-1-jo Nishi-17-chome, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan.
  • Terayama Y; Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
  • Kikuchi S; Department of Neurology, Hokkaido Medical Center, 1-1 Yamanote 5-jo 7-chome, Nishi-ku, Sapporo, Hokkaido 063-0005, Japan.
Clin Immunol ; 187: 95-101, 2018 02.
Article in En | MEDLINE | ID: mdl-29079163
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / B-Cell Activating Factor / Fingolimod Hydrochloride / Immunologic Memory / Immunosuppressive Agents / Multiple Sclerosis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / B-Cell Activating Factor / Fingolimod Hydrochloride / Immunologic Memory / Immunosuppressive Agents / Multiple Sclerosis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article