Pembrolizumab for treatment of advanced gastric and gastroesophageal junction adenocarcinoma.

Joshi, Smita S; Maron, Steven B; Catenacci, Daniel V

Joshi, Smita S; Maron, Steven B; Catenacci, Daniel V.

Affiliation

Joshi SS; Section of Hematology/Oncology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Maron SB; Section of Hematology/Oncology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Catenacci DV; The University of Chicago Medical Center & Biological Sciences, 900 East 57th Street, KCBD Building, Office 7128, Chicago, IL 60637, USA.

Future Oncol ; 14(5): 417-430, 2018 Feb.

Article in En | MEDLINE | ID: mdl-29094609

Subject(s)

Adenocarcinoma/drug therapy; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents, Immunological/therapeutic use; Esophageal Neoplasms/drug therapy; Esophagogastric Junction; Molecular Targeted Therapy; Stomach Neoplasms/drug therapy; Adenocarcinoma/metabolism; Adenocarcinoma/mortality; Adenocarcinoma/pathology; Antibodies, Monoclonal, Humanized/pharmacology; Antineoplastic Agents, Immunological/pharmacology; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biomarkers, Tumor; Clinical Trials as Topic; Esophageal Neoplasms/metabolism; Esophageal Neoplasms/mortality; Esophageal Neoplasms/pathology; Esophagogastric Junction/pathology; Humans; Neoplasm Metastasis; Neoplasm Staging; Programmed Cell Death 1 Receptor/antagonists & inhibitors; Retreatment; Stomach Neoplasms/metabolism; Stomach Neoplasms/mortality; Stomach Neoplasms/pathology; Treatment Outcome

Key words

MK-3475; PD-1; PD-L1; esophageal cancer; esophagogastric cancer; gastric cancer; gastroesophageal cancer; immune checkpoint blockade; immunotherapy; pembrolizumab

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Esophageal Neoplasms / Adenocarcinoma / Esophagogastric Junction / Molecular Targeted Therapy / Antibodies, Monoclonal, Humanized / Antineoplastic Agents, Immunological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Future Oncol Year: 2018 Type: Article Affiliation country: United States

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