Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis.
Paediatr Respir Rev
; 27: 60-68, 2018 Jun.
Article
in En
| MEDLINE
| ID: mdl-29108868
ABSTRACT
Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. The aim of this meta-analysis was to critically examine the current evidence on the association of vitamin E with childhood asthma and wheezing. We searched electronic databases for observational studies in English-language journals published from 2000 to 2016. The initial search found 420 titles; nineteen studies were eligible according to the abstracts and details, which included reporting asthma or wheeze as an outcome. None of the articles included in this meta-analysis reported side effects of vitamin E supplementation during pregnancy. This meta-analysis found that vitamin E supplementation during pregnancy influenced the risk of asthma. To better understand the effectiveness and safety of vitamin E in children with asthma, large-scale, well-designed and randomized controlled trials are needed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Vitamin E
/
Respiratory Sounds
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Systematic_reviews
Limits:
Child
/
Humans
Language:
En
Journal:
Paediatr Respir Rev
Journal subject:
PEDIATRIA
Year:
2018
Type:
Article