Whole-Genome Characterization of Bacillus cereus Associated with Specific Disease Manifestations.
Infect Immun
; 86(2)2018 02.
Article
in En
| MEDLINE
| ID: mdl-29158433
ABSTRACT
Bacillus cereus remains an important cause of infections, particularly in immunocompromised hosts. While typically associated with enteric infections, disease manifestations can be quite diverse and include skin infections, bacteremia, pneumonia, and meningitis. Whether there are any genetic correlates of bacterial strains with particular clinical manifestations remains unknown. To address this gap in understanding, we undertook whole-genome analysis of B. cereus strains isolated from patients with a range of disease manifestations, including noninvasive colonizing disease, superficial skin infections, and invasive bacteremia. Interestingly, strains involved in skin infection tended to form a distinct genetic cluster compared to isolates associated with invasive disease. Other disease manifestations, despite not being exclusively clustered, nonetheless had unique genetic features. The unique features associated with the specific types of infections ranged from traditional virulence determinants to metabolic pathways and gene regulators. These data represent the largest genetic analysis to date of pathogenic B. cereus isolates with associated clinical parameters.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacillus cereus
/
Whole Genome Sequencing
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Infect Immun
Year:
2018
Type:
Article
Affiliation country:
United States