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Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.
Forootan, Shiva S; Mutter, Fiona E; Kipar, Anja; Iwawaki, Takao; Francis, Ben; Goldring, Christopher E; Park, B Kevin; Copple, Ian M.
Affiliation
  • Forootan SS; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.
  • Mutter FE; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.
  • Kipar A; Institute of Global Health, University of Liverpool, Liverpool, L69 7BE, UK.
  • Iwawaki T; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, CH-8057, Switzerland.
  • Francis B; Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Ishikawa, 920-0293, Japan.
  • Goldring CE; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.
  • Park BK; Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GL, UK.
  • Copple IM; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.
Sci Rep ; 7(1): 16084, 2017 11 22.
Article in En | MEDLINE | ID: mdl-29167567
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Computer Systems / Imaging, Three-Dimensional / NF-E2-Related Factor 2 / Acetaminophen Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Computer Systems / Imaging, Three-Dimensional / NF-E2-Related Factor 2 / Acetaminophen Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: United kingdom