Multidisciplinary Approach to the Management of Lymphatic Malformations of the Head and Neck.
Otolaryngol Clin North Am
; 51(1): 159-172, 2018 Feb.
Article
in En
| MEDLINE
| ID: mdl-29217060
ABSTRACT
Lymphatic malformations (LMs) occur in 2.8 to 5 per 100,000 live births. Most involve the head and neck and they are equally common in men and women. They are developmental anomalies of unknown cause, although recent evidence suggests that an upregulation of the mammalian target of rapamycin (mTOR) pathway may be a causal factor leading to the overproduction of abnormal lymph vessels. These vessels are likely dilated lymphatic sacs sequestered from the lymphatic and venous systems. This overproduction results in the accumulation of lymph in dilated cystic spaces, which in turn results in the clinical features of an LM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Head and Neck Neoplasms
/
Lymphangioma
Limits:
Humans
Language:
En
Journal:
Otolaryngol Clin North Am
Year:
2018
Type:
Article