Development of pyrrolo[2,1-c][1,4]benzodiazepine ß-glucoside prodrugs for selective therapy of cancer.

Adiyala, Praveen Reddy; Tekumalla, Venkatesh; Sayeed, Ibrahim Bin; Nayak, V Lakshma; Nagarajan, Apoorva; Shareef, Mohd Adil; Nagaraju, Burri; Kamal, Ahmed

Adiyala, Praveen Reddy; Tekumalla, Venkatesh; Sayeed, Ibrahim Bin; Nayak, V Lakshma; Nagarajan, Apoorva; Shareef, Mohd Adil; Nagaraju, Burri; Kamal, Ahmed.

Affiliation

Adiyala PR; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Tekumalla V; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Sayeed IB; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Nayak VL; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Nagarajan A; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Shareef MA; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Nagaraju B; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Kamal A; Department of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Catalytic Chemistry Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: ahmedkamal@iict.res.in.

Bioorg Chem ; 76: 288-293, 2018 02.

Article in En | MEDLINE | ID: mdl-29223805

Subject(s)

Antineoplastic Agents/pharmacology; Benzodiazepines/pharmacology; Glucosides/pharmacology; Prodrugs/pharmacology; Pyrroles/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/metabolism; Antineoplastic Agents/toxicity; Benzodiazepines/chemical synthesis; Benzodiazepines/metabolism; Benzodiazepines/toxicity; Cell Line, Tumor; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Glucosides/chemical synthesis; Glucosides/metabolism; Glucosides/toxicity; Humans; Prodrugs/chemical synthesis; Prodrugs/metabolism; Prodrugs/toxicity; Pyrroles/chemical synthesis; Pyrroles/metabolism; Pyrroles/toxicity; beta-Glucosidase/metabolism

Key words

Cytotoxicity; Prodrugs; Pyrrolo[2,1-c][1,4]benzodiazepine; Selective therapy; ß-Glucoside

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Benzodiazepines / Prodrugs / Glucosides / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2018 Type: Article Affiliation country: India

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