Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity.
Elife
; 62017 12 18.
Article
in En
| MEDLINE
| ID: mdl-29251591
ABSTRACT
Cells of multi-cellular organisms evolve toward uni-cellularity in the form of cancer and, if humans intervene, continue to evolve in cell culture. During this process, gene dosage relationships may evolve in novel ways to cope with the new environment and may regress back to the ancestral uni-cellular state. In this context, the evolution of sex chromosomes vis-a-vis autosomes is of particular interest. Here, we report the chromosomal evolution in ~ 600 cancer cell lines. Many of them jettisoned either Y or the inactive X; thus, free-living male and female cells converge by becoming 'de-sexualized'. Surprisingly, the active X often doubled, accompanied by the addition of one haploid complement of autosomes, leading to an XA ratio of 23 from the extant ratio of 12. Theoretical modeling of the frequency distribution of XA karyotypes suggests that the 23 ratio confers a higher fitness and may reflect aspects of sex chromosome evolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sex Chromosomes
/
Adaptation, Biological
/
Chromosomes, Human
/
Cell Proliferation
Limits:
Humans
Language:
En
Journal:
Elife
Year:
2017
Type:
Article
Affiliation country:
China