ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells.

Fay, Marta M; Anderson, Paul J; Ivanov, Pavel

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells.

Fay, Marta M; Anderson, Paul J; Ivanov, Pavel.

Affiliation

Fay MM; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Anderson PJ; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: panderson@rics.bwh.harvard.edu.
Ivanov P; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: pivanov@rics.bwh.harvard.edu.

Cell Rep ; 21(12): 3573-3584, 2017 Dec 19.

Article in En | MEDLINE | ID: mdl-29262335

Subject(s)

Amyotrophic Lateral Sclerosis/etiology; C9orf72 Protein/chemistry; Cytoplasmic Granules/chemistry; Frontotemporal Dementia/etiology; Phase Transition; RNA, Messenger/chemistry; Animals; Cell Line; Cell Line, Tumor; G-Quadruplexes; Humans; Mice

Key words

C9ORF72; G-quadruplex; RNA; RNA granule; amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration; phase separation; stress granule

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Cytoplasmic Granules / Phase Transition / Frontotemporal Dementia / C9orf72 Protein / Amyotrophic Lateral Sclerosis Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2017 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google