Fulminant Cryptococcus neoformans infection with fatal pericardial tamponade in a patient with chronic myelomonocytic leukaemia who was treated with ruxolitinib: Case report and review of fungal pericarditis.
Mycoses
; 61(4): 245-255, 2018 Apr.
Article
in En
| MEDLINE
| ID: mdl-29280197
ABSTRACT
Cryptococcus neoformans is a saprophytic fungal pathogen that can cause serious illness in immune-compromised hosts and it presents with a wide variety of clinical symptoms. We present a fatal case of fulminant C. neoformans infection presenting as pericardial tamponade in a 71-year-old male with chronic myelomonocytic leukaemia undergoing chemotherapy with the JAK-STAT inhibitor ruxolitinib. We also review the published cases of fungal pericarditis/tamponade. In addition to illustrating an atypical presentation of C. neoformans, this case highlights the risk for opportunistic fungal infections in patients with haematological malignancies, especially the ones treated with small molecule kinase inhibitors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pericarditis
/
Pyrazoles
/
Cardiac Tamponade
/
Leukemia, Myelomonocytic, Chronic
/
Cryptococcosis
/
Immunologic Factors
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Mycoses
Journal subject:
MICROBIOLOGIA
Year:
2018
Type:
Article
Affiliation country:
United States