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Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
Krotee, Pascal; Griner, Sarah L; Sawaya, Michael R; Cascio, Duilio; Rodriguez, Jose A; Shi, Dan; Philipp, Stephan; Murray, Kevin; Saelices, Lorena; Lee, Ji; Seidler, Paul; Glabe, Charles G; Jiang, Lin; Gonen, Tamir; Eisenberg, David S.
Affiliation
  • Krotee P; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Griner SL; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Sawaya MR; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Cascio D; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Rodriguez JA; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Shi D; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147.
  • Philipp S; Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697.
  • Murray K; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Saelices L; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Lee J; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Seidler P; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095.
  • Glabe CG; Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697; Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 22252, Saudi Arabia.
  • Jiang L; Department of Neurology, Molecular Biology Institute, and Brain Research Institute (BRI), David Geffen School of Medicine, UCLA, Los Angeles, California, 90095.
  • Gonen T; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147.
  • Eisenberg DS; Howard Hughes Medical Institute, UCLA-United States Department of Energy (DOE) Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095. Electronic address: david@mbi.ucla.edu.
J Biol Chem ; 293(8): 2888-2902, 2018 02 23.
Article in En | MEDLINE | ID: mdl-29282295
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Models, Molecular / Amyloid beta-Peptides / Neurofibrillary Tangles / Islet Amyloid Polypeptide Language: En Journal: J Biol Chem Year: 2018 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Models, Molecular / Amyloid beta-Peptides / Neurofibrillary Tangles / Islet Amyloid Polypeptide Language: En Journal: J Biol Chem Year: 2018 Type: Article