Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy.

Azoury, M E; Filì, L; Bechara, R; Scornet, N; de Chaisemartin, L; Weaver, R J; Claude, N; Maillere, B; Parronchi, P; Joseph, D; Pallardy, M

Azoury, M E; Filì, L; Bechara, R; Scornet, N; de Chaisemartin, L; Weaver, R J; Claude, N; Maillere, B; Parronchi, P; Joseph, D; Pallardy, M.

Affiliation

Azoury ME; Inflammation, Chimiokines et Immunopathologie, INSERM, Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
Filì L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Bechara R; Inflammation, Chimiokines et Immunopathologie, INSERM, Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
Scornet N; BioCIS, Univ Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France.
de Chaisemartin L; Inflammation, Chimiokines et Immunopathologie, INSERM, Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
Weaver RJ; Hopital Bichat, Laboratoire d'Immunologie, APHP, Paris, France.
Claude N; Institut de Recherches Internationales Servier, Suresnes, France.
Maillere B; Institut de Recherches Internationales Servier, Suresnes, France.
Parronchi P; SIMOPRO, IBiTecS, CEA, Saclay, France.
Joseph D; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Pallardy M; BioCIS, Univ Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France.

Allergy ; 73(8): 1662-1672, 2018 Aug.

Article in En | MEDLINE | ID: mdl-29355985

Subject(s)

Drug Hypersensitivity/immunology; Epitopes, T-Lymphocyte/chemistry; Epitopes, T-Lymphocyte/immunology; Penicillin G/chemistry; Penicillin G/immunology; Serum Albumin, Human/chemistry; Serum Albumin, Human/immunology; Binding Sites; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; HLA-D Antigens/immunology; Haptens/immunology; Humans; Immunodominant Epitopes; Leukocytes, Mononuclear; Lymphocyte Activation; Peptides/immunology; Poisson Distribution; Protein Binding

Key words

T cell; allergy; drug allergy; hapten; penicillin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillin G / Epitopes, T-Lymphocyte / Drug Hypersensitivity / Serum Albumin, Human Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Allergy Year: 2018 Type: Article Affiliation country: France

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