Efficient production of trans-4-Hydroxy-l-proline from glucose by metabolic engineering of recombinant Escherichia coli.

Zhang, H-L; Zhang, C; Pei, C-H; Han, M-N; Xu, Z-D; Li, C-H; Li, W

Zhang, H-L; Zhang, C; Pei, C-H; Han, M-N; Xu, Z-D; Li, C-H; Li, W.

Affiliation

Zhang HL; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Zhang C; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Pei CH; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Han MN; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Xu ZD; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.
Li CH; HeBei Brant Pharmaceutical Co., Ltd., Shingjiazhuang, China.
Li W; Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, China.

Lett Appl Microbiol ; 66(5): 400-408, 2018 May.

Article in En | MEDLINE | ID: mdl-29432647

Subject(s)

Escherichia coli; Glucose/metabolism; Hydroxyproline/biosynthesis; Metabolic Engineering/methods; Proline/metabolism; Biocatalysis; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Glutamate-5-Semialdehyde Dehydrogenase/genetics; Glutamate-5-Semialdehyde Dehydrogenase/metabolism; Hydroxyproline/metabolism; Ketoglutaric Acids/metabolism; Mixed Function Oxygenases/metabolism; Phosphotransferases (Carboxyl Group Acceptor)/genetics; Phosphotransferases (Carboxyl Group Acceptor)/metabolism; Prolyl Hydroxylases/genetics; Prolyl Hydroxylases/metabolism

Key words

Trans-4-hydroxy-l-proline; bioconversion; metabolic engineering; proline 4-hydroxylases; recombinant Escherichia coli

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proline / Escherichia coli / Metabolic Engineering / Glucose / Hydroxyproline Language: En Journal: Lett Appl Microbiol Journal subject: MICROBIOLOGIA Year: 2018 Type: Article Affiliation country: China

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