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A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.
Briedé, Jacob J; Deferme, Lize; Wolters, Jarno E J; Claessen, Sandra M H; van den Beucken, Twan; Wagner, Richard J; van Breda, Simone G; Kleinjans, Jos C S.
Affiliation
  • Briedé JJ; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands. Electronic address: j.briede@maastrichtuniversity.nl.
  • Deferme L; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands; ExxonMobil Petroleum and Chemical, Hermeslaan 2, 1831 Machelen, Belgium.
  • Wolters JEJ; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
  • Claessen SMH; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
  • van den Beucken T; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
  • Wagner RJ; Département de médecine nucléaire et radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, J1H 5N4 Québec, Canada.
  • van Breda SG; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
  • Kleinjans JCS; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Toxicol In Vitro ; 48: 318-328, 2018 Apr.
Article in En | MEDLINE | ID: mdl-29432895
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Gene Expression Regulation / Oxidative Stress / Tert-Butylhydroperoxide / Genomics / 5-Methylcytosine Limits: Animals / Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Gene Expression Regulation / Oxidative Stress / Tert-Butylhydroperoxide / Genomics / 5-Methylcytosine Limits: Animals / Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2018 Type: Article