Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin.

Lobysheva, E; Taylor, C M; Marshall, G R; Kisselev, O G

Lobysheva, E; Taylor, C M; Marshall, G R; Kisselev, O G.

Affiliation

Lobysheva E; Department of Ophthalmology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Taylor CM; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marshall GR; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kisselev OG; Department of Ophthalmology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. Electronic address: kisselev@slu.edu.

Exp Eye Res ; 170: 51-57, 2018 05.

Article in En | MEDLINE | ID: mdl-29454859

Subject(s)

Cholagogues and Choleretics/metabolism; GTP-Binding Proteins/metabolism; Light; Rhodopsin/radiation effects; Taurochenodeoxycholic Acid/metabolism; Animals; Cattle; Opsins/chemistry; Protein Binding; Protein Structure, Secondary; Receptors, G-Protein-Coupled/chemistry; Receptors, G-Protein-Coupled/metabolism; Rhodopsin/chemistry; Rhodopsin/metabolism; Signal Transduction

Key words

Bile acid; Chemical biology; G protein; G proteincoupled receptor (GPCR); Molecular docking; Photoreceptor; Phototransduction; Retina; Rhodopsin; Signal transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhodopsin / Taurochenodeoxycholic Acid / Cholagogues and Choleretics / GTP-Binding Proteins / Light Limits: Animals Language: En Journal: Exp Eye Res Year: 2018 Type: Article Affiliation country: United States

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