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Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation.
Viganò, Elena; Gunawardana, Jay; Mottok, Anja; Van Tol, Tessa; Mak, Katina; Chan, Fong Chun; Chong, Lauren; Chavez, Elizabeth; Woolcock, Bruce; Takata, Katsuyoshi; Twa, David; Shulha, Hennady P; Telenius, Adèle; Kutovaya, Olga; Hung, Stacy S; Healy, Shannon; Ben-Neriah, Susana; Leroy, Karen; Gaulard, Philippe; Diepstra, Arjan; Kridel, Robert; Savage, Kerry J; Rimsza, Lisa; Gascoyne, Randy; Steidl, Christian.
Affiliation
  • Viganò E; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Gunawardana J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Mottok A; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Van Tol T; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Mak K; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Chan FC; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Chong L; Institute of Pathology, University of Würzburg, Würzburg, Germany.
  • Chavez E; Comprehensive Cancer Centre Mainfranken, Würzburg, Germany.
  • Woolcock B; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Takata K; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Twa D; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Shulha HP; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Telenius A; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Kutovaya O; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Hung SS; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Healy S; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Ben-Neriah S; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Leroy K; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Gaulard P; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Diepstra A; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Kridel R; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Savage KJ; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Rimsza L; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Gascoyne R; Department of Lymphoid Cancer Research, British Columbia Cancer Agency, Vancouver, Canada.
  • Steidl C; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Blood ; 131(18): 2036-2046, 2018 05 03.
Article in En | MEDLINE | ID: mdl-29467182
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Large B-Cell, Diffuse / STAT Transcription Factors / Janus Kinases / Interleukin-4 Receptor alpha Subunit / Mediastinal Neoplasms / Mutation Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Blood Year: 2018 Type: Article Affiliation country: Canada
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Large B-Cell, Diffuse / STAT Transcription Factors / Janus Kinases / Interleukin-4 Receptor alpha Subunit / Mediastinal Neoplasms / Mutation Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Blood Year: 2018 Type: Article Affiliation country: Canada