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Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time.
Soethoudt, Marjolein; Hoorens, Mark W H; Doelman, Ward; Martella, Andrea; van der Stelt, Mario; Heitman, Laura H.
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  • Soethoudt M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
  • Hoorens MWH; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
  • Doelman W; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
  • Martella A; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
  • van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands.
  • Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, University of Leiden, Einsteinweg 55, 2333 AR, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.
Biochem Pharmacol ; 152: 129-142, 2018 06.
Article in En | MEDLINE | ID: mdl-29574067
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Receptor, Cannabinoid, CB2 / Imidazolidines / Cannabinoid Receptor Agonists Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2018 Type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Receptor, Cannabinoid, CB2 / Imidazolidines / Cannabinoid Receptor Agonists Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2018 Type: Article Affiliation country: Netherlands