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A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.
Princiotto, Amy M; Vrbanac, Vladimir D; Melillo, Bruno; Park, Jongwoo; Tager, Andrew M; Smith, Amos B; Sodroski, Joseph; Madani, Navid.
Affiliation
  • Princiotto AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Vrbanac VD; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts.
  • Melillo B; Department of Chemistry, University of Pennsylvania, Philadelphia.
  • Park J; Department of Chemistry, University of Pennsylvania, Philadelphia.
  • Tager AM; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts.
  • Smith AB; Department of Chemistry, University of Pennsylvania, Philadelphia.
  • Sodroski J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Madani N; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts.
J Infect Dis ; 218(3): 471-475, 2018 07 02.
Article in En | MEDLINE | ID: mdl-29617845
ABSTRACT

Background:

Small-molecule CD4-mimetic compounds (CD4mc) inhibit human immunodeficiency virus (HIV-1) entry by blocking binding to the CD4 receptor and by premature triggering of the viral envelope glycoprotein (Env) spike.

Methods:

The efficacy of a CD4mc in protecting bone marrow-liver-thymus (BLT) humanized mice from vaginal HIV-1 challenge was evaluated.

Results:

Intravaginal application of the CD4mc JP-III-48, either before or simultaneously with virus challenge, protected BLT humanized mice from HIV-1JR-CSF infection in a dose- dependent manner.

Conclusion:

The direct antiviral effects of a CD4mc prevent HIV-1 infection in a murine model of sexual transmission.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / HIV Infections / HIV-1 / HIV Fusion Inhibitors / Biomimetics Limits: Animals Language: En Journal: J Infect Dis Year: 2018 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / HIV Infections / HIV-1 / HIV Fusion Inhibitors / Biomimetics Limits: Animals Language: En Journal: J Infect Dis Year: 2018 Type: Article