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A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway.
Hussain, Syed Saad; Rafi, Kinza; Faizi, Shaheen; Razzak, Zaid Abdul; Simjee, Shabana U.
Affiliation
  • Hussain SS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Rafi K; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Faizi S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Razzak ZA; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Simjee SU; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. shabana.simjee@iccs.edu.
Mol Cell Biochem ; 449(1-2): 105-115, 2018 Dec.
Article in En | MEDLINE | ID: mdl-29644528
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Protein p53 / Apoptosis / Diterpenes / Neuroblastoma / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Biochem Year: 2018 Type: Article Affiliation country: Pakistan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Protein p53 / Apoptosis / Diterpenes / Neuroblastoma / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Biochem Year: 2018 Type: Article Affiliation country: Pakistan