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Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.
Qin, Xian-Yang; Suzuki, Harukazu; Honda, Masao; Okada, Hikari; Kaneko, Shuichi; Inoue, Ikuyo; Ebisui, Etsuko; Hashimoto, Kosuke; Carninci, Piero; Kanki, Keita; Tatsukawa, Hideki; Ishibashi, Naoto; Masaki, Takahiro; Matsuura, Tomokazu; Kagechika, Hiroyuki; Toriguchi, Kan; Hatano, Etsuro; Shirakami, Yohei; Shiota, Goshi; Shimizu, Masahito; Moriwaki, Hisataka; Kojima, Soichi.
Affiliation
  • Qin XY; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan.
  • Suzuki H; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan.
  • Honda M; Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan.
  • Okada H; Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan.
  • Kaneko S; Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-0942 Ishikawa, Japan.
  • Inoue I; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan.
  • Ebisui E; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan.
  • Hashimoto K; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan.
  • Carninci P; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, 230-0045 Kanagawa, Japan.
  • Kanki K; Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, 683-8503 Tottori, Japan.
  • Tatsukawa H; Department of Basic Medicinal Sciences, Nagoya University Graduate School of Pharmaceutical Sciences, Nagoya, 464-8601 Aichi, Japan.
  • Ishibashi N; Tokyo New Drug Research Laboratories, Pharmaceutical Division, KOWA Co. Ltd., 189-0022 Tokyo, Japan.
  • Masaki T; Department of Laboratory Medicine, The Jikei University School of Medicine, 105-8461 Tokyo, Japan.
  • Matsuura T; Department of Laboratory Medicine, The Jikei University School of Medicine, 105-8461 Tokyo, Japan.
  • Kagechika H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 101-0062 Tokyo, Japan.
  • Toriguchi K; Department of Surgery, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Hatano E; Department of Surgery, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Shirakami Y; Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan.
  • Shiota G; Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, 683-8503 Tottori, Japan.
  • Shimizu M; Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan.
  • Moriwaki H; Department of Gastroenterology, Graduate School of Medicine, Gifu University, 501-1194 Gifu, Japan.
  • Kojima S; Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, 351-0198 Saitama, Japan; skojima@riken.jp.
Proc Natl Acad Sci U S A ; 115(19): 4969-4974, 2018 05 08.
Article in En | MEDLINE | ID: mdl-29686061
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Neoplastic Stem Cells / Gene Expression Regulation, Neoplastic / Carcinoma, Hepatocellular / Wnt Signaling Pathway / N-Myc Proto-Oncogene Protein / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Neoplastic Stem Cells / Gene Expression Regulation, Neoplastic / Carcinoma, Hepatocellular / Wnt Signaling Pathway / N-Myc Proto-Oncogene Protein / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Japan