Development of Fast-Dissolving Amorphous Solid Dispersion of Itraconazole by Melt Extrusion of its Mixture with Weak Organic Carboxylic Acid and Polymer.

Parikh, Tapan; Serajuddin, Abu T M

Parikh, Tapan; Serajuddin, Abu T M.

Affiliation

Parikh T; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York, 11439, USA.
Serajuddin ATM; Center of Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20903, USA.

Pharm Res ; 35(7): 127, 2018 Apr 25.

Article in En | MEDLINE | ID: mdl-29696402

Subject(s)

Carboxylic Acids/chemical synthesis; Chemistry, Pharmaceutical/methods; Drug Development/methods; Itraconazole/chemical synthesis; Polymers/chemical synthesis; Antifungal Agents/chemical synthesis; Antifungal Agents/metabolism; Carboxylic Acids/metabolism; Itraconazole/metabolism; Polymers/metabolism; Rheology/methods; Solubility; X-Ray Diffraction/methods

Key words

amorphous solid dispersion; dissolution enhancement; itraconazole; melt extrusion; weak organic acid

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / Carboxylic Acids / Chemistry, Pharmaceutical / Itraconazole / Drug Development Type of study: Prognostic_studies Language: En Journal: Pharm Res Year: 2018 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google