Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.

Humber, L G; Ferdinandi, E; Demerson, C A; Ahmed, S; Shah, U; Mobilio, D; Sabatucci, J; De Lange, B; Labbadia, F; Hughes, P

Humber, L G; Ferdinandi, E; Demerson, C A; Ahmed, S; Shah, U; Mobilio, D; Sabatucci, J; De Lange, B; Labbadia, F; Hughes, P.

Affiliation

Humber LG; Ayerst Laboratories Research, Inc., Princeton, New Jersey 08543-8000.

J Med Chem ; 31(9): 1712-9, 1988 Sep.

Article in En | MEDLINE | ID: mdl-2970548

Subject(s)

Indoleacetic Acids/chemical synthesis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage/drug effects; Cartilage/metabolism; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dinoprostone; Edema/drug therapy; Etodolac; Humans; Indoleacetic Acids/pharmacology; Indoleacetic Acids/urine; Male; Methylation; Oxidation-Reduction; Prostaglandins E/biosynthesis; Rats; Rats, Inbred Strains; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Indoleacetic Acids Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1988 Type: Article

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