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Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study.
Lee, Euna; Xing, Fangxu; Ahn, Sung; Reese, Timothy G; Wang, Ruopeng; Green, Jordan R; Atassi, Nazem; Wedeen, Van J; El Fakhri, Georges; Woo, Jonghye.
Affiliation
  • Lee E; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Xing F; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Ahn S; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Reese TG; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
  • Wang R; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
  • Green JR; Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts 02129, USA.
  • Atassi N; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA leecia@bc.edu, fxing1@mgh.harvard.edu, sung_m_ahn@college.harvard.edu, reese@nmr.mgh.harvard.edu, rpwang@nmr.mgh.harvard.edu, jgreen2@mghihp.edu, natassi@mgh.harvard.edu, van@nmr.mgh.har
  • Wedeen VJ; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
  • El Fakhri G; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Woo J; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
J Acoust Soc Am ; 143(4): EL248, 2018 04.
Article in En | MEDLINE | ID: mdl-29716267
ABSTRACT
Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder, which impairs tongue function for speech and swallowing. A widely used Diffusion Tensor Imaging (DTI) analysis pipeline is employed for quantifying differences in tongue fiber myoarchitecture between controls and ALS patients. This pipeline uses both high-resolution magnetic resonance imaging (hMRI) and DTI. hMRI is used to delineate tongue muscles, while DTI provides indices to reveal fiber connectivity within and between muscles. The preliminary results using five controls and two patients show quantitative differences between the groups. This work has the potential to provide insights into the detrimental effects of ALS on speech and swallowing.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tongue Diseases / Amyotrophic Lateral Sclerosis Type of study: Etiology_studies / Evaluation_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Acoust Soc Am Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tongue Diseases / Amyotrophic Lateral Sclerosis Type of study: Etiology_studies / Evaluation_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Acoust Soc Am Year: 2018 Type: Article Affiliation country: United States