Rhodium(III)-Catalyzed Annulation of 2-Alkenyl Anilides with Alkynes through C-H Activation: Direct Access to 2-Substituted Indolines.
Angew Chem Int Ed Engl
; 57(27): 8255-8259, 2018 07 02.
Article
in En
| MEDLINE
| ID: mdl-29726603
ABSTRACT
A RhIII complex featuring an electron-deficient η5 -cyclopentadienyl ligand catalyzed an unusual annulation between alkynes and 2-alkenyl anilides to form synthetically appealing 2-substituted indolines. Formally, the process can be viewed as an allylic amination with concomitant hydrocarbonation of the alkyne. Mechanistic experiments indicate that this transformation involves an unusual rhodium migration with a concomitant 1,5-H shift.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2018
Type:
Article
Affiliation country:
Spain