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Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.
Evers, Raymond; Piquette-Miller, Micheline; Polli, Joseph W; Russel, Frans G M; Sprowl, Jason A; Tohyama, Kimio; Ware, Joseph A; de Wildt, Saskia N; Xie, Wen; Brouwer, Kim L R.
Affiliation
  • Evers R; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Kenilworth, New Jersey, USA.
  • Piquette-Miller M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Polli JW; Mechanistic Safety and Drug Disposition, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Russel FGM; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Sprowl JA; Department of Pharmaceutical, Social and Administrative Sciences, School of Pharmacy, D'Youville College School, Buffalo, New York, USA.
  • Tohyama K; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company, Fujisawa, Kanagawa, Japan.
  • Ware JA; Department of Small Molecule Pharmaceutical Sciences, Genentech, South San Francisco, California, USA.
  • de Wildt SN; Department of Pharmacology and Toxicology and Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands, and Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Xie W; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
Clin Pharmacol Ther ; 104(5): 900-915, 2018 11.
Article in En | MEDLINE | ID: mdl-29756222
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Pharmacokinetics / Pharmaceutical Preparations / Acute Disease / Chronic Disease / Membrane Transport Modulators Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Clin Pharmacol Ther Year: 2018 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Pharmacokinetics / Pharmaceutical Preparations / Acute Disease / Chronic Disease / Membrane Transport Modulators Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Clin Pharmacol Ther Year: 2018 Type: Article Affiliation country: United States