Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder.
Mov Disord
; 33(6): 1016-1020, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29756641
ABSTRACT
BACKGROUND:
MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear.OBJECTIVE:
To study the role of MAPT variants in rapid eye movement sleep behavior disorder.METHODS:
Two cohorts were included (A) PD (n = 600), rapid eye movement sleep behavior disorder (n = 613) patients, and controls (n = 981); (B) dementia with Lewy bodies patients with rapid eye movement sleep behavior disorder (n = 271) and controls (n = 950). MAPT-associated variants and the entire coding sequence of MAPT were analyzed. Age-, sex-, and ethnicity-adjusted analyses were performed to examine the association between MAPT, PD, and rapid eye movement sleep behavior disorder.RESULTS:
MAPT-H2 variants were associated with PD (odds ratios 0.62-0.65; P = 0.010-0.019), but not with rapid eye movement sleep behavior disorder. In PD, the H1 haplotype odds ratio was 1.60 (95% confidence interval 1.12-2.28; P = 0.009), and the H2 odds ratio was 0.68 (95% confidence interval 0.48-0.96; P = 0.03). The H2/H1 haplotypes were not associated with rapid eye movement sleep behavior disorder.CONCLUSIONS:
Our results confirm the protective effect of the MAPT-H2 haplotype in PD, and define its components. Furthermore, our results suggest that MAPT does not play a major role in rapid eye movement sleep behavior disorder, emphasizing different genetic background than in PD in this locus. © 2018 International Parkinson and Movement Disorder Society.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Tau Proteins
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Genetic Predisposition to Disease
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REM Sleep Behavior Disorder
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Polymorphism, Single Nucleotide
Type of study:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limits:
Aged
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Mov Disord
Journal subject:
NEUROLOGIA
Year:
2018
Type:
Article
Affiliation country:
China