Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.

Yang, Rong; Cai, Ting-Ting; Wu, Xiao-Jun; Liu, Yi-Na; He, Jia; Zhang, Xiao-Shi; Ma, Gang; Li, Jiang

Yang, Rong; Cai, Ting-Ting; Wu, Xiao-Jun; Liu, Yi-Na; He, Jia; Zhang, Xiao-Shi; Ma, Gang; Li, Jiang.

Affiliation

Yang R; State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
Cai TT; State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
Wu XJ; State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
Liu YN; Department of Colon Cancer, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
He J; State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
Zhang XS; Department of Biotherapy, Sun Yat-Sen University Cancer Centre, Guangzhou, China.
Ma G; State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
Li J; Department of Biotherapy, Sun Yat-Sen University Cancer Centre, Guangzhou, China.

Immunology ; 155(2): 263-272, 2018 10.

Article in En | MEDLINE | ID: mdl-29770434

Subject(s)

Adaptor Proteins, Signal Transducing/genetics; Biomarkers, Tumor; Colorectal Neoplasms/genetics; Colorectal Neoplasms/immunology; Myeloid-Derived Suppressor Cells/immunology; Myeloid-Derived Suppressor Cells/metabolism; PTEN Phosphohydrolase/genetics; Phosphoproteins/genetics; Adaptor Proteins, Signal Transducing/metabolism; Adult; Aged; Aged, 80 and over; Biomarkers; Cell Proliferation; Colorectal Neoplasms/mortality; Colorectal Neoplasms/pathology; Female; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; PTEN Phosphohydrolase/metabolism; Phosphoproteins/metabolism; Prognosis; Transcription Factors; Tumor Microenvironment; YAP-Signaling Proteins; Young Adult

Key words

colorectal cancer; myeloid-derived suppressor cell; phosphatase and tensin homologue; prognosis; yes-associated protein 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Colorectal Neoplasms / Biomarkers, Tumor / Adaptor Proteins, Signal Transducing / PTEN Phosphohydrolase / Myeloid-Derived Suppressor Cells Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Immunology Year: 2018 Type: Article Affiliation country: China

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