Sumoylation and phosphorylation: hidden and overt links.
J Exp Bot
; 69(19): 4583-4590, 2018 08 31.
Article
in En
| MEDLINE
| ID: mdl-29846689
ABSTRACT
Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In particular, many components of the SUMO conjugation system are phosphoproteins, and some regulators and enzymes of protein phosphorylation can be sumoylated. Equally important, however, a number of proteins can be subject to both modifications. These substrates also have the capacity to connect stimuli transmitted via sumoylation with those transmitted via phosphorylation. As a prime example, we review data suggesting that nitrate reductase is a hub that integrates cues from these two modifications. Powerful proteomics approaches allowed the identification of additional common substrates, paving the way for studies to understand, on a broader basis, the cross-talk of phosphorylation with sumoylation and how it contributes to plant growth.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphorylation
/
Plant Proteins
/
Small Ubiquitin-Related Modifier Proteins
/
Sumoylation
Language:
En
Journal:
J Exp Bot
Journal subject:
BOTANICA
Year:
2018
Type:
Article
Affiliation country:
Austria