Total Synthesis and Antimicrobial Activities of All Stereoisomers of (16 Z,20 E)-Eushearilide and (16 E,20 E)-Eushearilide.
J Org Chem
; 83(15): 7886-7899, 2018 08 03.
Article
in En
| MEDLINE
| ID: mdl-29847953
ABSTRACT
As promising antifungal agents, the eight stereoisomers of eushearilide, including the natural compound, were synthesized relying on an asymmetric Mukaiyama aldol reaction, Julia-Kocienski olefination, and Shiina macrolactonization. Moreover, their in vitro antimicrobial activities against some fungi and bacteria were evaluated by the disk-diffusion method, which revealed that not only natural eushearilide but also its stereoisomers exhibited significant antimicrobial activity against a variety of fungi and bacteria.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphorylcholine
/
Macrolides
/
Anti-Infective Agents
Language:
En
Journal:
J Org Chem
Year:
2018
Type:
Article
Affiliation country:
Japan