Dielectrophoretic Nanoparticle Aggregation for On-Demand Surface Enhanced Raman Spectroscopy Analysis.
Anal Chem
; 90(13): 7930-7936, 2018 07 03.
Article
in En
| MEDLINE
| ID: mdl-29863841
ABSTRACT
Rapid chemical identification of drugs of abuse in biological fluids such as saliva is of growing interest in healthcare and law enforcement. Accordingly, a label-free detection platform that accepts biological fluid samples is of great practical value. We report a microfluidics-based dielectrophoresis-induced surface enhanced Raman spectroscopy (SERS) device, which is capable of detecting physiologically relevant concentrations of methamphetamine in saliva in under 2 min. In this device, iodide-modified silver nanoparticles are trapped and released on-demand using electrodes integrated in a microfluidic channel. Principal component analysis (PCA) is used to reliably distinguish methamphetamine-positive samples from the negative control samples. Passivation of the electrodes and flow channels minimizes microchannel fouling by nanoparticles, which allows the device to be cleared and reused multiple times.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silver
/
Spectrum Analysis, Raman
/
Metal Nanoparticles
Language:
En
Journal:
Anal Chem
Year:
2018
Type:
Article
Affiliation country:
United States