Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods.

Loret, Thomas; Rogerieux, Françoise; Trouiller, Bénédicte; Braun, Anne; Egles, Christophe; Lacroix, Ghislaine

Loret, Thomas; Rogerieux, Françoise; Trouiller, Bénédicte; Braun, Anne; Egles, Christophe; Lacroix, Ghislaine.

Affiliation

Loret T; Institut National de l'Environnement Industriel et des Risques (INERIS), (DRC/VIVA/TOXI), Parc Technologique ALATA - BP 2, F-60550, Verneuil-en-Halatte, France.
Rogerieux F; Université de Technologie de Compiègne (UTC), Laboratoire BioMécanique et BioIngénierie (BMBI), UMR CNRS 7338, 60205, Compiègne, France.
Trouiller B; Institut National de l'Environnement Industriel et des Risques (INERIS), (DRC/VIVA/TOXI), Parc Technologique ALATA - BP 2, F-60550, Verneuil-en-Halatte, France.
Braun A; Institut National de l'Environnement Industriel et des Risques (INERIS), (DRC/VIVA/TOXI), Parc Technologique ALATA - BP 2, F-60550, Verneuil-en-Halatte, France.
Egles C; Institut National de l'Environnement Industriel et des Risques (INERIS), (DRC/VIVA/TOXI), Parc Technologique ALATA - BP 2, F-60550, Verneuil-en-Halatte, France.
Lacroix G; Université de Technologie de Compiègne (UTC), Laboratoire BioMécanique et BioIngénierie (BMBI), UMR CNRS 7338, 60205, Compiègne, France.

Part Fibre Toxicol ; 15(1): 25, 2018 06 04.

Article in En | MEDLINE | ID: mdl-29866184

Subject(s)

Alveolar Epithelial Cells/drug effects; Cerium/toxicity; Inhalation Exposure/adverse effects; Macrophages/drug effects; Nanostructures/toxicity; Titanium/toxicity; A549 Cells; Alveolar Epithelial Cells/immunology; Animal Use Alternatives; Animals; Bronchoalveolar Lavage Fluid/cytology; Bronchoalveolar Lavage Fluid/immunology; Cerium/chemistry; Cerium/pharmacokinetics; Coculture Techniques; Cytokines/immunology; Dose-Response Relationship, Drug; Humans; Macrophages/immunology; Male; Nanostructures/chemistry; Particle Size; Predictive Value of Tests; Rats, Wistar; Reactive Oxygen Species/immunology; Titanium/chemistry; Titanium/pharmacokinetics

Key words

Acute exposure; Air-liquid interface; Alternative toxicity testing; In vivo - in vitro comparison; Poorly soluble nanomaterials; Pulmonary toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Titanium / Cerium / Inhalation Exposure / Nanostructures / Alveolar Epithelial Cells / Macrophages Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Part Fibre Toxicol Journal subject: TOXICOLOGIA Year: 2018 Type: Article Affiliation country: France

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