Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis.

Zhen, Yuxuan; Lee, Iris J; Finkelman, Fred D; Shao, Wen-Hai

Zhen, Yuxuan; Lee, Iris J; Finkelman, Fred D; Shao, Wen-Hai.

Affiliation

Zhen Y; Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267 USA.
Lee IJ; Division of Nephrology, Department of Medicine, Temple University, Philadelphia, PA 19140 USA.
Finkelman FD; Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267 USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati OH 45229 USA.
Shao WH; Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267 USA. Electronic address: shaowi@ucmail.uc.edu.

J Autoimmun ; 93: 37-44, 2018 09.

Article in En | MEDLINE | ID: mdl-29895432

Subject(s)

Benzocycloheptenes/pharmacology; Immunologic Factors/pharmacology; Lupus Nephritis/drug therapy; Mesangial Cells/drug effects; Molecular Targeted Therapy/methods; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins/genetics; Receptor Protein-Tyrosine Kinases/genetics; Triazoles/pharmacology; Administration, Oral; Animals; Antibodies/administration & dosage; Cell Line, Transformed; Drug Administration Schedule; Gene Expression Regulation; Glomerular Basement Membrane/drug effects; Glomerular Basement Membrane/immunology; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/immunology; Lupus Nephritis/chemically induced; Lupus Nephritis/genetics; Lupus Nephritis/immunology; Mesangial Cells/immunology; Mesangial Cells/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/immunology; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/immunology; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Receptor Protein-Tyrosine Kinases/immunology; Signal Transduction; Sp1 Transcription Factor/antagonists & inhibitors; Sp1 Transcription Factor/genetics; Sp1 Transcription Factor/immunology; Sp3 Transcription Factor/antagonists & inhibitors; Sp3 Transcription Factor/genetics; Sp3 Transcription Factor/immunology; Axl Receptor Tyrosine Kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Benzocycloheptenes / Lupus Nephritis / Proto-Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Protein Kinase Inhibitors / Mesangial Cells / Molecular Targeted Therapy / Immunologic Factors Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article

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