[The swelling behavior of choline fenofibrate hydrogel matrix tablets using dynamic image analysis].
Yao Xue Xue Bao
; 51(11): 1770-6, 2016 11.
Article
in Zh
| MEDLINE
| ID: mdl-29908136
ABSTRACT
The purpose of this study is to investigate the effects of formulation on the swelling behavior of choline fenofibrate hydrogel matrix tablets and reveal the relation between swelling property and release profile using dynamic image analysis. The volume swelling ratio (SR) and height/width (k) could evaluate the swelling behavior of matrix tablets well. The mount of hydroxypropyl methylcellulose (HPMC) and the ratio between K15M and K4M affected the volume swelling ratio, while PVP didn't. The three factors all impacted k, which was an indicator of the strength of the gel formed by HPMC. The accumulative release ratio and SR, the rate of swelling and the rate of release were compared. The proper model equations were established for the results with an excellent correlation. The results prove that there is a strong relevance between the swelling behavior and release property. This study provides a guideline in the study design for hydrogel matrix tablets.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fenofibrate
/
Choline
/
Hydrogels
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
2016
Type:
Article