Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5+ CD11c+ cells.
Parasite Immunol
; 40(8): e12566, 2018 08.
Article
in En
| MEDLINE
| ID: mdl-29920694
ABSTRACT
Trichuris muris is a natural mouse helminth pathogen which establishes infection specifically in the caecum and proximal colon. The rapid expulsion of T. muris in resistant mouse strains is associated with the induction of a protective T helper cell type 2 (Th2)-polarized immune response. Susceptible mouse strains, in contrast, mount an inappropriate Th1 response to T. muris infection. Expression of the chemokine CXCL13 by stromal follicular dendritic cells attracts CXCR5-expressing cells towards the B-cell follicles. Previous studies using a complex in vivo depletion model have suggested that CXCR5-expressing conventional dendritic cells (cDC) help regulate the induction of Th2-polarized responses. Here, transgenic mice with CXCR5 deficiency specifically restricted to CD11c+ cells were used to determine whether the specific absence CXCR5 on CD11c+ cells such as cDC would influence susceptibility to oral T. muris infection by affecting the Th1/Th2 balance. We show that in contrast to control mice, those which lacked CXCR5 expression on CD11c+ cells failed to clear T. muris infection and developed cytokine and antibody responses that suggested a disturbed Th1/Th2 balance with enhanced IFN-γ expression. These data suggest an important role of CXCR5-expressing CD11c+ cells such as cDC in immunity to oral T. muris infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trichuriasis
/
Trichuris
/
CD11c Antigen
/
Receptors, CXCR5
Limits:
Animals
Language:
En
Journal:
Parasite Immunol
Year:
2018
Type:
Article
Affiliation country:
United kingdom