Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2-Mediated Yes-Associated Protein Activation.

Liu, Runping; Li, Xiaojiaoyang; Hylemon, Phillip B; Zhou, Huiping

Liu, Runping; Li, Xiaojiaoyang; Hylemon, Phillip B; Zhou, Huiping.

Affiliation

Liu R; Department of Microbiology and Immunology, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia.
Li X; Department of Microbiology and Immunology, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia.
Hylemon PB; Department of Microbiology and Immunology, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia.
Zhou H; Department of Microbiology and Immunology, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia. Electronic address: huiping.zhou@vcuhealth.org.

Am J Pathol ; 188(9): 2042-2058, 2018 09.

Article in En | MEDLINE | ID: mdl-29963993

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Adenocarcinoma/pathology; Esophageal Neoplasms/pathology; Gene Expression Regulation, Neoplastic/drug effects; Neoplastic Stem Cells/pathology; Phosphoproteins/metabolism; Receptors, Lysosphingolipid/metabolism; Taurocholic Acid/pharmacology; Adaptor Proteins, Signal Transducing/genetics; Adenocarcinoma/drug therapy; Adenocarcinoma/metabolism; Cholagogues and Choleretics/pharmacology; Esophageal Neoplasms/drug therapy; Esophageal Neoplasms/metabolism; Humans; Neoplasm Invasiveness; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Phosphoproteins/genetics; Receptors, Lysosphingolipid/genetics; Sphingosine-1-Phosphate Receptors; Transcription Factors; Tumor Cells, Cultured; YAP-Signaling Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Taurocholic Acid / Neoplastic Stem Cells / Esophageal Neoplasms / Adenocarcinoma / Gene Expression Regulation, Neoplastic / Adaptor Proteins, Signal Transducing / Receptors, Lysosphingolipid Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Am J Pathol Year: 2018 Type: Article

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