Green tea supplementation promotes leukocyte telomere length elongation in obese women.
Nutr Hosp
; 35(3): 570-575, 2018 Jun 10.
Article
in En
| MEDLINE
| ID: mdl-29974764
ABSTRACT
INTRODUCTION:
inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL).OBJECTIVES:
we evaluated the effect of decaffeinated green tea supplementation in obese women on TL.METHODS:
we conducted a cross-sectional interventional study with ten obese (body mass index [BMI] > 40 kg/m²) and eight normal weight (BMI > 18.5 and < 24.9 kg/m²) women (age between 27 and 48 years). The supplementation was carried out with capsules (each contained 450.7 mg of epigallocatechin-3-gallate) during eight weeks. Anthropometric and dietary intake assessment, and blood collection (for biochemical and TL analysis by quantitative PCR) were performed before and after supplementation. Normal weight patients were evaluated at a single moment.RESULTS:
we observed a significant increase on TL after supplementation (1.57 ± 1.1 to 3.2 ± 2.1 T/Sratio; p < 0.05). Moreover, we found shorter TL in obese patients (day 0) when compared to normal weight individuals (3.2 ± 1.9 T/Sratio; p < 0.05) and an inverse association between TL and BMI, even after age adjustment (beta = -0.527; r² = 0.286; IC = -0.129, -0.009).CONCLUSION:
obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tea
/
Catechin
/
Telomere
/
Dietary Supplements
/
Leukocytes
/
Obesity
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Nutr Hosp
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2018
Type:
Article