Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model.

Karthikeyan, Subbulakshmi; Russo, Angela; Dean, Matthew; Lantvit, Daniel D; Endsley, Michael; Burdette, Joanna E

Karthikeyan, Subbulakshmi; Russo, Angela; Dean, Matthew; Lantvit, Daniel D; Endsley, Michael; Burdette, Joanna E.

Affiliation

Karthikeyan S; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Russo A; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Dean M; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Lantvit DD; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Endsley M; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA; Medical College of Wisconsin, Department of Obstetrics & Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI, 53226-3522, USA.
Burdette JE; Center for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA. Electronic address: joannab@uic.edu.

Cancer Lett ; 433: 221-231, 2018 10 01.

Article in En | MEDLINE | ID: mdl-29981811

Subject(s)

Carcinoma, Ovarian Epithelial/pathology; Fallopian Tube Neoplasms/pathology; Ovarian Neoplasms/pathology; Prolactin/metabolism; Animals; CRISPR-Cas Systems; Carcinogenesis/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Mice; Mice, Nude; Prolactin/genetics; Proto-Oncogene Proteins/metabolism; Receptors, Prolactin/biosynthesis; Wnt Proteins/metabolism

Key words

High grade serous ovarian cancer and p53 phosphorylation; Prolactin; Prolactin receptor; Spontaneous fallopian tube derived ovarian cancer model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Prolactin / Fallopian Tube Neoplasms / Carcinoma, Ovarian Epithelial Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Lett Year: 2018 Type: Article Affiliation country: United States

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