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Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition.
Denton, Travis T; Srivastava, Pramod; Xia, Zuping; Chen, Gang; Watson, Christy J W; Wynd, Alec; Lazarus, Philip.
Affiliation
  • Denton TT; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Srivastava P; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Xia Z; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Chen G; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Watson CJW; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Wynd A; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
  • Lazarus P; Department of Pharmaceutical Sciences , College of Pharmacy, Washington State University , Spokane , Washington 99202 , United States.
J Med Chem ; 61(16): 7065-7086, 2018 08 23.
Article in En | MEDLINE | ID: mdl-29995408
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Microsomes, Liver / Enzyme Inhibitors / Cytochrome P-450 CYP2A6 / Methylamines Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Microsomes, Liver / Enzyme Inhibitors / Cytochrome P-450 CYP2A6 / Methylamines Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article Affiliation country: United States