Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches.

Keller, Heiko; Weickhmann, A Katharina; Bock, Thomas; Wöhnert, Jens

Keller, Heiko; Weickhmann, A Katharina; Bock, Thomas; Wöhnert, Jens.

Affiliation

Keller H; Institute for Molecular Biosciences and Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Weickhmann AK; Institute for Molecular Biosciences and Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Bock T; Institute for Molecular Biosciences and Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Wöhnert J; Institute for Molecular Biosciences and Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.

RNA ; 24(10): 1390-1402, 2018 10.

Article in En | MEDLINE | ID: mdl-30006500

Subject(s)

Adenine/metabolism; Cyclic GMP/analogs & derivatives; Nucleotides, Cyclic/metabolism; RNA/genetics; RNA/metabolism; Riboswitch; Adenine/chemistry; Cyclic GMP/chemistry; Cyclic GMP/metabolism; Ligands; Magnetic Resonance Spectroscopy; Nucleotides, Cyclic/chemistry; Protein Binding; RNA/chemistry; RNA, Bacterial/chemistry; RNA, Bacterial/genetics; RNA, Bacterial/metabolism; Vibrio cholerae/genetics

Key words

NMR; c-GAMP; c-di-GMP; hydrogen bonds; protonated adenine; riboswitch

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / Adenine / Cyclic GMP / Riboswitch / Nucleotides, Cyclic Language: En Journal: RNA Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: Germany

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