Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse.

Mastromina, Ioanna; Verrier, Laure; Silva, Joana Clara; Storey, Kate G; Dale, J Kim

Mastromina, Ioanna; Verrier, Laure; Silva, Joana Clara; Storey, Kate G; Dale, J Kim.

Affiliation

Mastromina I; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Verrier L; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Silva JC; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Storey KG; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Dale JK; Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK j.k.dale@dundee.ac.uk.

Development ; 145(14)2018 07 30.

Article in En | MEDLINE | ID: mdl-30061166

Subject(s)

Biological Clocks/genetics; Body Patterning/genetics; CLOCK Proteins/genetics; Mesoderm/cytology; Mesoderm/metabolism; Proto-Oncogene Proteins c-myc/metabolism; Signal Transduction/genetics; Stem Cells/metabolism; Animals; CLOCK Proteins/metabolism; Cell Differentiation; Down-Regulation/genetics; Embryo, Mammalian/metabolism; Female; Fibroblast Growth Factor 8/metabolism; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Developmental; Humans; Mesoderm/embryology; Mice; RNA, Messenger/genetics; RNA, Messenger/metabolism; Somites/embryology; Somites/metabolism; Stem Cells/cytology; Tail/embryology; Wnt Proteins/metabolism

Key words

Embryo; Myc; Neuromesodermal progenitors; Presomitic mesoderm; Segmentation clock

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Biological Clocks / Signal Transduction / Proto-Oncogene Proteins c-myc / Body Patterning / CLOCK Proteins / Mesoderm Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 2018 Type: Article Affiliation country: United kingdom

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